Black raspberry soaking spirit was prepared with black raspberry as raw material and buckwheat base liquor as the base, the soaking process conditions were optimized by single factor and response surface tests, and the anti-gout effect was evaluated by mouse hyperuricemia model and acute gouty joint swelling model. The results showed that the optimal preparation process conditions of black raspberry soaking spirit were as follows: liquid and solid ratio 1∶1 (ml∶g), soaking time 60 d, and alcohol content of buckwheat base liquor 49%vol. Under the optimal conditions, the xanthine oxidase (XOD) inhibition rate of raspberry soaking spirit was 42.68%, and the total flavonoid content was 0.97 mg/ml. The high dose group of black raspberry soaking spirit could significantly reduce the uric acid content and XOD activity in serum of model mouse and increase the uric acid content in urine (P＜0.05). The uric acid content and XOD activity in serum decreased 121.93 μmol/L and 13.93 U/L, respectively, the uric acid content in urine increased 131.78 μmol/L, and the acute gouty joint swelling degree decreased 5.37%. Black raspberry soaking spirit had definite anti-gout effect, which provided basic data for product development.