以Wistar大鼠为研究对象，探讨药桑葡萄果酒对高脂血症大鼠血脂的调节作用。收集动物试验各组动物血清、肝脏、心脏及脂肪组织，测定血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及相应的抗氧化指标，并对大鼠肝脏和心脏进行组织病理学检查。结果表明，经药桑葡萄果酒灌胃后，与模型组相比，药桑葡萄果酒高、中、低组的TC分别下降了27.87%、36.96%和22.80%（P＜0.05），TG分别下降了49.38%、62.63%和43.51%（P＜0.05）。药桑葡萄果酒不同剂量组能显著提高大鼠血清超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性（P＜0.05），显著降低血清丙二醛（MDA）的含量（P＜0.05）。适量的药桑葡萄果酒可抑制大鼠肝脏中脂质的积累，改善脂肪肝病变和脂质代谢紊乱，从而降低高脂饮食大鼠体内血脂水平。

Using Wistar rats as research objects, the regulating effect of a medicine-mulberry and grape wine on blood lipids in hyperlipidemia rats were explored. The serum, liver, heart and adipose tissue of experimental animals in each group were collected, and serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were determined, the corresponding antioxidant indexes and histopathological examination of rat liver and heart were performed. The results showed that after gavage of the medicine- mulberry and grape wine, compared with the model group, the TC content in high, medium and low dose group decreased by 27.87%, 36.96% and 22.80% respectively (P＜0.05), and the TG content decreased by 49.38%, 62.63% and 43.51%, respectively (P＜0.05). The wine with different dosage significantly increased the activities of serum superoxide dismutase (SOD) and catalase (CAT) (P＜0.05), and significantly reduced the content of serum malondialdehyde (MDA) (P＜0.05). Moderate amount of the wine could inhibit the accumulation of lipids in the rats liver, improve fatty liver lesions and lipid metabolism disorders, thereby reducing blood lipid levels in high-fat diet rats.