[1] JEONG Y K, PARK J U, BAEK H, et al. Purification and biochemical characterization of a fibrinolytic enzyme from Bacillus subtilis BK-17[J]. World J Microbiol Biotechnol, 2001, 17(1): 89-92.
[2] FUJITA M, HONG K, ITO Y, et al. Transport of nattokinase across the rat intestinal tract[J]. Biol Pharm Bull, 1995b, 18(9): 1194-1196.
[3] WANG S L, WU Y Y, LIANG T W. Purification and biochemical characterization of a nattokinase by conversion of shrimp shell with Bacillus subtilis TKU007[J]. New Biotechnol, 2011, 28(2): 196-202.
[4] 韩雅莉，李伟张. 地鳖纤溶蛋白纯化及性质研究[J]. 生物工程学报，2006， 22（4）：639-643.
[5] 温贵则，冯金连，郭芳兰. 蛇毒纤溶酶溶栓作用的研究进展[J]. 现代医药卫生，2011，27（3）：387-389.
[6] 孙　杨. 低分子量藻酸双酯钠的制备及其抗血栓活性研究[D]. 青岛：中国海洋大学，2011.
[7] LU X, ZHANG R H, PENG Y, et al. Highly efficient gene expression of a fibrinolytic enzyme(subtilisin DFE) in Bacillus subtilis mediated by the promoter of α-amylase gene from Bacillus amyloliquefaciens DC-4[J]. Biotechnol Lett, 2004, 26(17): 1365-1369.
[8] KIRTANE A R, SADHUKHA T, KIM H, et al. Fibrinolytic enzyme cotherapy improves tumor perfusion and therapeutic efficacy of anticancer nanomedicine[J]. Cancer Res, 2017, 77(6): 1465-1475.
[9] SUMI H, HAMADA H, TSUSHIMA H, et al. A novel fibrinolytic enzyme (nattokinase)in the vegetable cheese natto,atypical and popular soybean food in the Japanese diet[J]. Experientia, 1987, 43(10): 1110-1111.
[10] KIM W, CHOI H, KIM Y, et al. Purification and characterization of a fibrinolytic enzyme produced from Bacillus sp. strain CK11-4 screened from Chung kook[J]. Appl Environ Microbiol, 1996, 62(7): 2482-2488.
[11] LUO W H, GUO Y, HAN S Y. High-level expression of Douchi fibri- nolytic enzyme in Bacillus subtilis WB800[J]. Chinese J Appl Environ Biol, 2007, 13(4): 565-569.
[12] 彭　勇，张义正. 豆豉溶栓酶产生菌的筛选及其酶学性质的初步研究[J]. 高技术通讯，2002，12（2）：30-34.
[13] 朱春节，汤祝华，谢秀祯. 一株新的豆豉纤溶酶产生菌的研究[J]. 基因组学与应用生物学，2011，30（1）：7-15.
[14] 马　晶，高玉荣. 产纤溶酶菌株的筛选鉴定及其生长条件研究[J]. 农产品加工·学刊，2013（14）：28-30.
[15] 龚福明，李晓然，宋园亮，等. 红河传统发酵豆豉中高纤溶活性菌株的分离筛选及其纤溶酶基因分析[J]. 现代食品科技，2014，30（8）：76- 81，211.
[16] CHENG G, HE L, SUN Z, et al. Purification and biochemical characterization of a novel fibrinolytic enzyme from Streptomyces sp. P3[J]. J Microbiol Biot, 2015, 25(9): 1449-1459.
[17] TANEJA K, BAJAJ B K, KUMAR S, et al. Production, purification and characterization of fibrinolytic enzyme from Serratia sp. KG-2-1 using optimized media[J]. Biotech, 2017, 7(3): 184-198.
[18] 袁　军，李国良，沈榕强，等.豆豉溶栓酶产生菌Bacillussubtilis LD- 8547的诱变选育[J]. 江西农业大学学报，2012，34（6）：1251-1255.
[19] 卞承荫，黄舒婷，潘大仁，等. 利用紫外线和EMS诱变选育高产枯草芽孢杆菌[J]. 福建农林大学学报：自然科学版，2014，43（3）：312-315.
[20] 齐海萍，冮　洁，胡文忠，等. 豆豉纤溶酶基因的克隆及其在枯草杆菌中的表达[J]. 大豆科学，2012，31（1）：159-161.
[21] SOUZA F A S D D, SALES A E, SILVA P E C E, et al. Optimization of production, biochemical characterization and in vitro, evaluation of the therapeutic potential of fibrinolytic enzymes from a new Bacillus amyloliquefaciens[J]. Macromol Res, 2016, 24(7): 587-595.
[22] VIJAYARAGHAVAN P, RAJENDRAN P, PRAKASH VINCENT S G, et al. Novel sequential screening and enhanced production of fibrinolytic enzyme by Bacillus sp. IND12 using response surface methodology in solid-state fermentation[J]. Biomed Res Int, 2017, doi:org/10.1155/ 2017/3909657.
[23] 张　旭，唐　非，彭良斌，等. 豆豉中解淀粉芽孢杆菌发酵产纤溶酶[J]. 食品研究与开发，2013，34（24）：239-243.
[24] 王　昶. 豆豉纤溶酶高产菌株XY-1的诱变育种及产酶条件研究[D]. 武汉：华中科技大学，2013.
[25] 杨　林，谢雅雯，魏文苹，等. 响应面法优化解淀粉芽孢杆菌发酵产豆豉纤溶酶的工艺条件[J]. 基因组学与应用生物学，2016，35（8）：2092-2099.
[26] KIM J S, KIM J E, CHOI B S, et al.Purification and characterization of fibrinolytic metalloprotease from Perenniporia fraxinea mycelia[J]. Mycological Research, 2008, 112(8): 990-998.
[27] AVHAD D N, RATHOD V K. Application of mixed modal resin for purification of a fibrinolytic enzyme[J]. Prep Biochem Biotechnol, 2016, 46(3): 222-228.
[28] CHANG C T, WANG P M, HUNG Y F, et al. Purification and biochemical properties of a fibrinolytic enzyme from Bacillus subtilis-fermented red bean[J]. Food Chem, 2012, 133(4): 1611-1617.
[29] 温　健，潘师翰，焉凯舟，等. 两种粗提纯法对纤溶酶纯化效果的比较研究[J]. 中国酿造，2014，33（9）：17-21.
[30] 王鹏娇，孟小夏，张　敏，等. 大孔树脂纯化豆豉溶栓酶的工艺优选[J]. 中国实验方剂学杂志，2014，20（11）：30-33.
[31] 胡国军，吴天祥. 豆豉纤溶酶活性检测及其纯化研究[J]. 中国酿造，2011，30（8）：109-114.
[32] SUN Z, LIU P, CHENG G, et al. A fibrinolytic protease AfeE from Streptomyces sp. CC5, with potent thrombolytic activity in a mouse model[J]. Int J Biol Macromol, 2016, 85: 346-354.
[33] CHOI J H, KIM J E, KIM S, et al. Purification and partial characterization of a low molecular fibrinolytic serine metalloprotease C142 from the culture supernatant of Bacillus subtilis C142[J]. Int J Biol Macromol, 2017, 10(104): 724-731.
[34] 张　雪，袁洪水，辛　欣，等. 豆豉纤溶酶组分S-7FE-1的酶学性质及体外溶栓特性分析[J]. 中国食品学报，2012，12（10）：40-46.
[35] YUAN J, YANG J, ZHUANG Z, et al. Thrombolytic effects of Douchi fibrinolytic enzyme from Bacillus subtilis LD-8547 in vitro and in vivo[J]. Bmc Biotechnology, 2012, 12(1): 36-44.
[36] ALBUQUERQUE W, NASCIMENTO T, BRAND?魨O-COSTA R, et al. Static magnetic field effects on proteases with fibrinolytic activity produced by Mucor subtilissimus[J]. Bioelectromagnetics, 2016, 38(2):109-120.
[37] WANG Y J, ZHOU G L, SHEN M H. Protective effects of fibrinolytic enzyme from Lyophyllum ulmarium on vascular endothelial cells injury in rats[J]. Food Sci Technol, 2016, 37(1): 171-175.
[38] TAKABAYASHI T, IMOTO Y, SAKASHITA M, et al. Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus[J]. Allerg Int, 2017, doi：org/10.1016/j.alit.2017.03.007.
[39] KIM H S, HAN O K, KWAK Y S. Complete genome sequence and functional study of the fibrinolytic enzyme-producing bacterium Leuconostoc holzapfelii 5H4, a silage probiotic[J]. J Genom, 2017(5): 32- 35.
[40] 陈　亮. 豆豉解淀粉芽孢杆菌纤溶酶的生理功能及分离纯化[D]. 广州：华南理工大学，2012.
[41] 张　婵，李小东，王成涛. 豆豉纤溶酶载纳米脂质体的制备与表征[J]. 中国食品学报，2014，14（7）：32-38.
[42] 张　婵，李小东，王成涛. 豆豉纤溶酶纳米脂质体的肠吸收效率研究[J]. 中国食品学报，2014，14（6）：28-35.
[43] 关晨晨. 豆豉纤溶酶的分离纯化、酶学性质的研究及微胶囊的制备[D]. 哈尔滨：东北林业大学，2010.
[44] 李大鹏，高玉荣，马　晶. 富含纤溶酶低盐豆酱加工工艺及品质分析[J]. 中国酿造，2014，33（5）：157-160.